Endocrine Abstracts

Case history: A 26 year old lady presented in 1999 with a 3 year history of worsening headache, increased sweating, excessive tiredness and progressive enlargement of hands and feet. She was otherwise well and had no family history of pituitary tumors, hypercalcaemia or renal stones. On examination she had typical facial features of acromegaly and acral enlargement. Her blood pressure was normal and visual fields were full.Investigations: Oral Glucose To...

Background: Assessment of psychological burden of disease forms one criterion for accreditation of a cancer specialist center. Patient Health Questionnaire-4 (PHQ-4), a validated self-report ultra-short questionnaire was used to assess anxiety and depression level in patients with GEP NETs, attending the clinics at an ENETS Centre of Excellence.Methods: PHQ-4 was completed during routine outpatient visits over a three month period by 48 patients, who wer...

Introduction: Orbital metastases from Neuroendocrine tumours (NET) are reported to be very rare, and can be the primary presentation or become evident up to 20 years after diagnosis. We report a series presented in the NET MDT, where ocular metastasis occurred.Case series: A 69-yr-old woman presented with blurred vision, pain and perception of a lump around the left eye. MRI showed a lacrimal gland mass within the orbit. Excision biopsy revealed a TTF1-p...

Background: Intracardiac metastasis of carcinoid tumours are rare (incidence 2–4%). Their presence without carcinoid valvulopathy or carcinoid syndrome is unusual.Case Discussions: A 70 year old male presented with abdominal pain. CT imaging revealed a small intestinal tumor with liver and mesenteric metastasis. Biopsy showed a neuroendocrine tumour (NET). Clinical and biochemical evidence of functionality was absent. He underwent definitive small b...

The granulation pattern of somatotroph adenoma is well known to be associated with differing clinical and biochemical characteristics and it has been shown that sparsely granulated tumors respond poorly to commonly used somatostatin analogs. We report a challenging case of acromegaly with a sparsely granulated tumor, resistant to multiple modalities of treatment given over several years and ultimately achieving biochemical control with pasireotide. A 26-year-old lady presented...